Sharyn Cosby Ministries started in 1998 when Rev. Cosby accepted the call to ministry. Starting in the correctional system and ministry in the streets with those in the margins.
Ordained through the Azusa Fellowship, in 2000 Cosby developed a ministry team that traveled ministering wherever called and frequently held services in correctional facilities. Two years later and under the leading of the Holy Spirit, the name was later changed to In The Spirit Ministries (ITSM) in 2002 and continued outreach in the margins.
During this time, Rev. Cosby later was completing her theological education at Phillips Theological Seminary. A year after completing her Masters in Divinity, her ordination through the Azusa Fellowship was affirmed by the Christian Church (Disciples of Oklahoma) in 2008.